The 48th Fighter Wing's 'Boss Bird' aircraft! Originally assigned to the 494th, this aircraft became the 48FW flagship aircraft some time in early 2020.
The markings represent the three squadrons that made up the 48FW at that time - the 492nd Bolars/Madhatters (F-15E), the 493rd Grim Reapers (F-15C/D), and the 494th Panthers (F-15E).